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穆峰达® (替尔泊肽注射液)

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替尔泊肽对胃排空有影响吗?
本文旨在提供关于替尔泊肽对胃排空是否有影响的相关医学信息,仅供医疗卫生专业人士参考。

CN_cFAQ_TZP021_Z1H_GASTRIC_EMPTYING_EFFECTS
CN_cFAQ_TZP021_Z1H_GASTRIC_EMPTYING_EFFECTSzh-CN

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天然 GIP 和 GIP 类似物均未显示对胃排空有影响。1-4

GLP-1 受体激动剂给药后胃排空延迟已得到公认,并被假设为导致血糖、食欲和食物摄入减少的因素之一。5-7

与选择性 GLP-1 RA 受体激动剂相比,替尔泊肽 对胃排空延迟有相似影响。1

参考文献

1Urva S, Coskun T, Loghin C, et al. The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists. Diabetes Obes Metab. 2020;22(10):1886-1891. https://doi.org/10.1111/dom.14110

2Edholm T, Degerblad M, Grybäck P, et al. Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. Neurogastroenterol Motil. 2010;22(11):1191-1200. https://doi.org/10.1111/j.1365-2982.2010.01554.x

3Meier JJ, Goetze O, Anstipp J, et al. Gastric inhibitory polypeptide does not inhibit gastric emptying in humans. Am J Physiol Endcrinol Metab. 2004;286(4):E621-E625. https://doi.org/10.1152/ajpendo.00499.2003

4Nauck MA, Baller B, Meier JJ. Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes. 2004;53(suppl 3):S190-S196. https://doi.org/10.2337/diabetes.53.suppl_3.S190

5Flint A, Raben A, Ersbøll AK, et al. The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. Int J Obes. 2001;25(6):781-792. https://doi.org/10.1038/sj.ijo.0801627

6Marathe CS, Rayner CK, Jones KL, Horowitz M. Effects of GLP-1 and incretin-based therapies on gastrointestinal motor function. Exp Diabetes Res. 2011;2011:279530. https://doi.org/10.1155/2011/279530

7Smits MM, Tonneijck L, Muskiet MH, et al. Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas. Diabetes Obes Metab. 2016;18(3):224-235. https://doi.org/10.1111/dom.12593

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