a在 ITT 人群中的比较,使用 Cochran-Mantel-Haenszel 检验调整汇总中心数据,缺失数据使用无应答者填补法。
b次要疗效终点,即第 24 周的 PASI 100 是受 Ⅰ 类错误控制但没有达到优效性。第 24 周的 PASI 100 的非劣效性分析是预设的且达到,但非 Ⅰ 类错误控制。
上次审阅日期:2023年7月26日
参考文献
1Blauvelt A, Papp K, Gottlieb A, et al; the IXORA-R Study Group. A head-to-head comparison of ixekizumab versus guselkumab in patients with moderate-to-severe plaque psoriasis: 12-week efficacy, safety, and speed of response from a randomized, double-blinded trial. Br J Dermatol. 2020;182(6):1348-1358. http://dx.doi.org/10.1111/bjd.18851
2Blauvelt A, Leonardi C, Elewski B, et al; the IXORA-R Study Group. A head-to-head comparison of ixekizumab versus guselkumab in patients with moderate-to-severe plaque psoriasis: 24-week efficacy and safety results from a randomised, double-blinded trial. Br J Dermatol. 2021;184(6):1047-1058. https://doi.org/10.1111/bjd.19509
3Data on file, Eli Lilly and Company and/or one of its subsidiaries.